Compound Detail
CHEMBL5028838
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Basic Information
| ChEMBL ID | CHEMBL5028838 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | AMXZGMCPHWGQGT-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
335.3
MW (Da)
0.70
ALogP
7
HBA
4
HBD
155.0
PSA (Ų)
0.22
QED
0
Ro5 Violations
1
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 5.02
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Death-associated protein kinase 1 CHEMBL2558 | IC50 | 5.02 | 5.02 | 9600.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Death-associated protein kinase 1 | IC50 | = | 9600.0 | nM | 5.02 | Inhibition of DAPK1 (1 to 285 residues) (unknown origin) expressed in Escherichi... | 36645394 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 36645394 | 10.1021/acs.jmedchem.2c01606 | Death-associated protein kinase 1 | 1 |
Data from ChEMBL 36 via Core Engine