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Compound Detail

CHEMBL503679

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Cn1c([N+](=O)[O-])cnc1/C=C/c1ccc2ccccc2c1

Basic Information

ChEMBL ID CHEMBL503679
Phase Preclinical
Structure Type MOL
InChI Key OVOXYFCCLZWVHT-VQHVLOKHSA-N
2
Targets
3
Activities
2
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

279.3
MW (Da)
3.65
ALogP
4
HBA
0
HBD
61.0
PSA (Ų)
0.54
QED
0
Ro5 Violations
3
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C16H13N3O2
MW 279.30
Aromatic Rings 3
Heavy Atoms 21
NP-Likeness -0.71

Activity Summary

EC50 2 meas. best 7.22
IC50 1 meas. best 4.01

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Giardia intestinalis
CHEMBL612652
EC50 7.22 7.22 60.0 2
HeLa
CHEMBL399
IC50 4.01 4.01 97723.7 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
19480409 10.1021/jm900356n Giardia intestinalis 2
19480409 10.1021/jm900356n HeLa 1
19480409 10.1021/jm900356n ADMET 1

Data from ChEMBL 36 via Core Engine