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Assay Detail

CHEMBL1004985

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Functional
Antigiardial activity against Giardia lamblia trophozoites isolates after 2 days by bactiter-glo viability assay
ChEMBL ↗
74
Total Activities
37
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Giardia intestinalis
Confidence 1 — Organism
Curated By Autocuration

Target

Giardia intestinalis (CHEMBL612652) ↗
Type ORGANISM
Organism Giardia intestinalis

Publication

Synthesis and electrochemistry of 2-ethenyl and 2-ethanyl derivatives of 5-nitroimidazole and antimicrobial activity against Giardia lamblia.
Valdez CA, Tripp JC, Miyamoto Y, Kalisiak J, Hruz P, Andersen YS, Brown SE, Kangas K, Arzu LV, Davids BJ, Gillin FD, Upcroft JA, Upcroft P, Fokin VV, Smith DK, Sharpless KB, Eckmann L.
J Med Chem (2009) 52 : 4038 -4053
PubMed 19480409 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 74 6.87 7.66

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL497429 — — 2 7.66
CHEMBL501842 — — 2 7.47
CHEMBL497021 — — 2 7.41
CHEMBL442901 — — 2 7.40
CHEMBL497227 — — 2 7.39
CHEMBL497427 — — 2 7.33
CHEMBL524984 — — 2 7.31
CHEMBL506970 — — 2 7.31
CHEMBL497432 — — 2 7.28
CHEMBL497424 — — 2 7.28
CHEMBL503679 — — 2 7.22
CHEMBL450304 — — 2 7.22
CHEMBL522740 — — 2 7.19
CHEMBL497022 — — 2 7.16
CHEMBL500893 — — 2 7.16
CHEMBL524985 — — 2 7.14
CHEMBL522244 — — 2 7.12
CHEMBL497229 — — 2 7.09
CHEMBL497425 — — 2 7.03
CHEMBL504553 — — 2 7.01
CHEMBL449181 — — 2 7.00
CHEMBL522246 — — 2 6.81
CHEMBL497631 — — 2 6.79
CHEMBL501780 — — 2 6.68
CHEMBL522402 — — 2 6.65
CHEMBL524983 — — 2 6.63
CHEMBL497230 — — 2 6.55
CHEMBL524078 — — 2 6.50
CHEMBL497428 — — 2 6.47
CHEMBL443874 — — 2 6.46

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL497429 — EC50 = 22.0 nM 7.66
CHEMBL497429 — EC50 = 21.88 nM 7.66
CHEMBL501842 — EC50 = 33.88 nM 7.47
CHEMBL501842 — EC50 = 34.0 nM 7.47
CHEMBL497021 — EC50 = 39.0 nM 7.41
CHEMBL497021 — EC50 = 38.9 nM 7.41
CHEMBL442901 — EC50 = 40.0 nM 7.40
CHEMBL442901 — EC50 = 39.81 nM 7.40
CHEMBL497227 — EC50 = 40.74 nM 7.39
CHEMBL497227 — EC50 = 41.0 nM 7.39
CHEMBL497427 — EC50 = 46.77 nM 7.33
CHEMBL497427 — EC50 = 47.0 nM 7.33
CHEMBL524984 — EC50 = 49.0 nM 7.31
CHEMBL506970 — EC50 = 48.98 nM 7.31
CHEMBL524984 — EC50 = 48.98 nM 7.31
CHEMBL506970 — EC50 = 49.0 nM 7.31
CHEMBL497424 — EC50 = 52.48 nM 7.28
CHEMBL497432 — EC50 = 52.0 nM 7.28
CHEMBL497432 — EC50 = 52.48 nM 7.28
CHEMBL497424 — EC50 = 52.0 nM 7.28
CHEMBL450304 — EC50 = 60.26 nM 7.22
CHEMBL450304 — EC50 = 60.0 nM 7.22
CHEMBL503679 — EC50 = 60.0 nM 7.22
CHEMBL503679 — EC50 = 60.26 nM 7.22
CHEMBL522740 — EC50 = 64.57 nM 7.19
CHEMBL522740 — EC50 = 65.0 nM 7.19
CHEMBL497022 — EC50 = 69.0 nM 7.16
CHEMBL500893 — EC50 = 69.0 nM 7.16
CHEMBL497022 — EC50 = 69.18 nM 7.16
CHEMBL500893 — EC50 = 69.18 nM 7.16
CHEMBL524985 — EC50 = 72.44 nM 7.14
CHEMBL524985 — EC50 = 72.0 nM 7.14
CHEMBL522244 — EC50 = 75.86 nM 7.12
CHEMBL522244 — EC50 = 76.0 nM 7.12
CHEMBL497229 — EC50 = 81.0 nM 7.09
CHEMBL497229 — EC50 = 81.28 nM 7.09
CHEMBL497425 — EC50 = 93.33 nM 7.03
CHEMBL497425 — EC50 = 93.0 nM 7.03
CHEMBL504553 — EC50 = 98.0 nM 7.01
CHEMBL504553 — EC50 = 97.72 nM 7.01
CHEMBL449181 — EC50 = 100.0 nM 7.00
CHEMBL449181 — EC50 = 100.0 nM 7.00
CHEMBL522246 — EC50 = 155.0 nM 6.81
CHEMBL522246 — EC50 = 154.88 nM 6.81
CHEMBL497631 — EC50 = 162.0 nM 6.79
CHEMBL497631 — EC50 = 162.18 nM 6.79
CHEMBL501780 — EC50 = 208.93 nM 6.68
CHEMBL501780 — EC50 = 209.0 nM 6.68
CHEMBL522402 — EC50 = 223.87 nM 6.65
CHEMBL522402 — EC50 = 224.0 nM 6.65