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Compound Detail

CHEMBL504553

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Cn1c([N+](=O)[O-])cnc1/C=C/c1ccsc1

Basic Information

ChEMBL ID CHEMBL504553
Phase Preclinical
Structure Type MOL
InChI Key PMISHSOTVGJZHL-NSCUHMNNSA-N
1
Targets
6
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names

Molecular Properties

235.3
MW (Da)
2.56
ALogP
5
HBA
0
HBD
61.0
PSA (Ų)
0.61
QED
0
Ro5 Violations
3
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C10H9N3O2S
MW 235.27
Aromatic Rings 2
Heavy Atoms 16
NP-Likeness -1.91

Activity Summary

EC50 6 meas. best 7.61

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Giardia intestinalis
CHEMBL612652
EC50 7.61 6.8433 24.6 6

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
19480409 10.1021/jm900356n Giardia intestinalis 8
19480409 10.1021/jm900356n HeLa 1
19480409 10.1021/jm900356n ADMET 1
19480409 10.1021/jm900356n Mus musculus 1

Data from ChEMBL 36 via Core Engine