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Assay Detail

CHEMBL1004983

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antigiardial activity against metronidazole-resistant Giardia lamblia isolate 713 trophozoite after 2 days by bactiter-glo viability assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Giardia intestinalis
Confidence 1 — Organism
Curated By Autocuration

Target

Giardia intestinalis (CHEMBL612652)
Type ORGANISM
Organism Giardia intestinalis

Publication

Synthesis and electrochemistry of 2-ethenyl and 2-ethanyl derivatives of 5-nitroimidazole and antimicrobial activity against Giardia lamblia.
Valdez CA, Tripp JC, Miyamoto Y, Kalisiak J, Hruz P, Andersen YS, Brown SE, Kangas K, Arzu LV, Davids BJ, Gillin FD, Upcroft JA, Upcroft P, Fokin VV, Smith DK, Sharpless KB, Eckmann L.
J Med Chem (2009) 52 : 4038 -4053
PubMed 19480409 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 17 7.24 8.09

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL506970 1 8.09
CHEMBL524984 1 7.74
CHEMBL497021 1 7.69
CHEMBL501842 1 7.69
CHEMBL504553 1 7.61
CHEMBL497227 1 7.59
CHEMBL524985 1 7.52
CHEMBL497432 1 7.49
CHEMBL497427 1 7.49
CHEMBL497424 1 7.44
CHEMBL522244 1 7.29
CHEMBL501780 1 6.99
CHEMBL524078 1 6.76
CHEMBL443874 1 6.74
CHEMBL497428 1 6.64
CHEMBL497433 1 6.46
CHEMBL137 METRONIDAZOLE 4.0 1 5.83

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL506970 EC50 = 8.128 nM 8.09
CHEMBL524984 EC50 = 18.2 nM 7.74
CHEMBL497021 EC50 = 20.42 nM 7.69
CHEMBL501842 EC50 = 20.42 nM 7.69
CHEMBL504553 EC50 = 24.55 nM 7.61
CHEMBL497227 EC50 = 25.7 nM 7.59
CHEMBL524985 EC50 = 30.2 nM 7.52
CHEMBL497432 EC50 = 32.36 nM 7.49
CHEMBL497427 EC50 = 32.36 nM 7.49
CHEMBL497424 EC50 = 36.31 nM 7.44
CHEMBL522244 EC50 = 51.29 nM 7.29
CHEMBL501780 EC50 = 102.33 nM 6.99
CHEMBL524078 EC50 = 173.78 nM 6.76
CHEMBL443874 EC50 = 181.97 nM 6.74
CHEMBL497428 EC50 = 229.09 nM 6.64
CHEMBL497433 EC50 = 346.74 nM 6.46
CHEMBL137 METRONIDAZOLE EC50 = 1479.11 nM 5.83