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Compound Detail

CHEMBL497433

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Cn1c([N+](=O)[O-])cnc1/C=C/c1ccccc1-c1ccccc1

Basic Information

ChEMBL ID CHEMBL497433
Phase Preclinical
Structure Type MOL
InChI Key JHIHBOJTUVXACK-VAWYXSNFSA-N
1
Targets
6
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

305.3
MW (Da)
4.17
ALogP
4
HBA
0
HBD
61.0
PSA (Ų)
0.54
QED
0
Ro5 Violations
4
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C18H15N3O2
MW 305.34
Aromatic Rings 3
Heavy Atoms 23
NP-Likeness -0.70

Activity Summary

EC50 6 meas. best 6.46

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Giardia intestinalis
CHEMBL612652
EC50 6.46 6.02 346.7 6

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
19480409 10.1021/jm900356n Giardia intestinalis 8
19480409 10.1021/jm900356n HeLa 1
19480409 10.1021/jm900356n ADMET 1

Data from ChEMBL 36 via Core Engine