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Compound Detail

CHEMBL501842

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Cn1c([N+](=O)[O-])cnc1/C=C/c1ccco1

Basic Information

ChEMBL ID CHEMBL501842
Phase Preclinical
Structure Type MOL
InChI Key NWVMZFWCENIGSN-SNAWJCMRSA-N
2
Targets
7
Activities
2
Assay Types
0
PK Parameters
4
Publications
0
Known Names

Molecular Properties

219.2
MW (Da)
2.09
ALogP
5
HBA
0
HBD
74.1
PSA (Ų)
0.58
QED
0
Ro5 Violations
3
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C10H9N3O3
MW 219.20
Aromatic Rings 2
Heavy Atoms 16
NP-Likeness -1.32

Activity Summary

EC50 6 meas. best 7.69
IC50 1 meas. best 4.03

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Giardia intestinalis
CHEMBL612652
EC50 7.69 7.1383 20.4 6
HeLa
CHEMBL399
IC50 4.03 4.03 93325.4 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
19480409 10.1021/jm900356n Giardia intestinalis 10
19480409 10.1021/jm900356n HeLa 1
19480409 10.1021/jm900356n ADMET 1
19480409 10.1021/jm900356n Mus musculus 1

Data from ChEMBL 36 via Core Engine