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Compound Detail

CHEMBL522244

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Cn1ccnc1/C=C/c1ncc([N+](=O)[O-])n1C

Basic Information

ChEMBL ID CHEMBL522244
Phase Preclinical
Structure Type MOL
InChI Key XEROUWHMUNEVHX-ONEGZZNKSA-N
2
Targets
7
Activities
2
Assay Types
0
PK Parameters
4
Publications
0
Known Names

Molecular Properties

233.2
MW (Da)
1.23
ALogP
6
HBA
0
HBD
78.8
PSA (Ų)
0.59
QED
0
Ro5 Violations
3
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C10H11N5O2
MW 233.23
Aromatic Rings 2
Heavy Atoms 17
NP-Likeness -1.20

Activity Summary

EC50 6 meas. best 7.29
IC50 1 meas. best 4.04

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Giardia intestinalis
CHEMBL612652
EC50 7.29 6.8533 51.3 6
HeLa
CHEMBL399
IC50 4.04 4.04 91201.1 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
19480409 10.1021/jm900356n Giardia intestinalis 11
19480409 10.1021/jm900356n HeLa 1
19480409 10.1021/jm900356n ADMET 1
19480409 10.1021/jm900356n Mus musculus 1

Data from ChEMBL 36 via Core Engine