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Compound Detail

CHEMBL524984

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Cn1c([N+](=O)[O-])cnc1/C=C/c1ccccc1Br

Basic Information

ChEMBL ID CHEMBL524984
Phase Preclinical
Structure Type MOL
InChI Key MVXIFILSCDGEOV-VOTSOKGWSA-N
2
Targets
7
Activities
2
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

308.1
MW (Da)
3.26
ALogP
4
HBA
0
HBD
61.0
PSA (Ų)
0.65
QED
0
Ro5 Violations
3
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C12H10BrN3O2
MW 308.13
Aromatic Rings 2
Heavy Atoms 18
NP-Likeness -1.17

Activity Summary

EC50 6 meas. best 7.74
IC50 1 meas. best 4.14

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Giardia intestinalis
CHEMBL612652
EC50 7.74 7.2033 18.2 6
HeLa
CHEMBL399
IC50 4.14 4.14 72443.6 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
19480409 10.1021/jm900356n Giardia intestinalis 8
19480409 10.1021/jm900356n HeLa 1
19480409 10.1021/jm900356n ADMET 1

Data from ChEMBL 36 via Core Engine