Compound Detail
CHEMBL5072020
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Nc1nc(-c2cccc(-n3ccc4cc(C5CC5)cc(F)c4c3=O)c2CO)c2cc(C3=CCNCC3)[nH]c2n1
Basic Information
| ChEMBL ID | CHEMBL5072020 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | DURVPEAYOPCPRO-UHFFFAOYSA-N |
2
Targets
5
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
522.6
MW (Da)
4.40
ALogP
7
HBA
4
HBD
121.8
PSA (Ų)
0.27
QED
1
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 5 meas. best 9.39
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Tyrosine-protein kinase BTK CHEMBL5251 | IC50 | 9.39 | 9.145 | 0.4 | 4 |
| OCI-Ly10 CHEMBL4483285 | IC50 | 7.01 | 7.01 | 98.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Tyrosine-protein kinase BTK | IC50 | = | 0.41 | nM | 9.39 | Inhibition Activity Assay: The kinase activity was measured using QuickScout Scr... | - |
| Tyrosine-protein kinase BTK | IC50 | = | 0.65 | nM | 9.19 | Inhibition of human BTK-A using phosphorylated substrate in presence of ATP by m... | 34529443 |
| Tyrosine-protein kinase BTK | IC50 | = | 0.99 | nM | 9.0 | Inhibition of human BTK C481S mutant using phosphorylated substrate in presence ... | 34529443 |
| Tyrosine-protein kinase BTK | IC50 | = | 0.99 | nM | 9.0 | Inhibitory Activity Assay: The kinase activity was measured using QuickScout Scr... | - |
| OCI-Ly10 | IC50 | = | 98.0 | nM | 7.01 | Antiproliferative activity against human OCILY10 cells assessed as reduction in ... | 34529443 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 34529443 | 10.1021/acs.jmedchem.1c01279 | Tyrosine-protein kinase BTK | 2 |
| 34529443 | 10.1021/acs.jmedchem.1c01279 | OCI-Ly10 | 1 |
Data from ChEMBL 36 via Core Engine