Compound Detail
CHEMBL5082464
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Basic Information
| ChEMBL ID | CHEMBL5082464 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | LMZYDQKZHDRDQF-UHFFFAOYSA-N |
4
Targets
4
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
394.4
MW (Da)
1.74
ALogP
8
HBA
1
HBD
108.4
PSA (Ų)
0.63
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 4 meas. best 6.5
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Fibroblast growth factor receptor 1 CHEMBL3650 | IC50 | 6.5 | 6.5 | 315.0 | 1 |
| Fibroblast growth factor receptor 3 CHEMBL2742 | IC50 | 6.28 | 6.28 | 520.0 | 1 |
| Fibroblast growth factor receptor 2 CHEMBL4142 | IC50 | 6.27 | 6.27 | 540.0 | 1 |
| Fibroblast growth factor receptor 4 CHEMBL3973 | IC50 | 5.72 | 5.72 | 1921.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Fibroblast growth factor receptor 1 | IC50 | = | 315.0 | nM | 6.5 | Inhibition of human FGFR1 (459 to 765 residues) expressed in Escherichia coli BL... | 34129329 |
| Fibroblast growth factor receptor 3 | IC50 | = | 520.0 | nM | 6.28 | Inhibition of human FGFR3 (450 to 758 residues) expressed in Escherichia coli BL... | 34129329 |
| Fibroblast growth factor receptor 2 | IC50 | = | 540.0 | nM | 6.27 | Inhibition of human FGFR2 (458 to 768 residues) expressed in Escherichia coli BL... | 34129329 |
| Fibroblast growth factor receptor 4 | IC50 | = | 1921.0 | nM | 5.72 | Inhibition of human FGFR4 (445 to 753 residues) expressed in Escherichia coli BL... | 34129329 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 34129329 | 10.1021/acs.jmedchem.1c00174 | Fibroblast growth factor receptor 1 | 1 |
| 34129329 | 10.1021/acs.jmedchem.1c00174 | Fibroblast growth factor receptor 2 | 1 |
| 34129329 | 10.1021/acs.jmedchem.1c00174 | Fibroblast growth factor receptor 3 | 1 |
| 34129329 | 10.1021/acs.jmedchem.1c00174 | Fibroblast growth factor receptor 4 | 1 |
Data from ChEMBL 36 via Core Engine