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Compound Detail

CHEMBL50831

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C[C@H]1OC2(CCN(C)CC2)CC1=O

Basic Information

ChEMBL ID CHEMBL50831
Phase Preclinical
Structure Type MOL
InChI Key OODDNJQTVFMGCF-MRVPVSSYSA-N
2
Targets
2
Activities
1
Assay Types
1
PK Parameters
3
Publications
0
Known Names

Molecular Properties

183.2
MW (Da)
0.83
ALogP
3
HBA
0
HBD
29.5
PSA (Ų)
0.56
QED
0
Ro5 Violations
0
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C10H17NO2
MW 183.25
Aromatic Rings 0
Heavy Atoms 13
NP-Likeness 0.72

Activity Summary

Ki 2 meas. best 4.58

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Muscarinic acetylcholine receptor M1
CHEMBL276
Ki 4.58 4.58 26000.0 1
Muscarinic acetylcholine receptor M2
CHEMBL309
Ki 4.43 4.43 37000.0 1

Pharmacokinetic Data

Parameter Value Units Species
KA 4.5 uM Cavia porcellus

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
- 10.1016/0960-894X(95)00301-9 Muscarinic acetylcholine receptor M1 2
- 10.1016/0960-894X(95)00301-9 Muscarinic acetylcholine receptor M2 2
- 10.1016/0960-894X(95)00301-9 Muscarinic acetylcholine receptor M3 2

Data from ChEMBL 36 via Core Engine