Compound Detail
CHEMBL5089161
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C=CC(=O)Nc1cc(Nc2nccc(Nc3cn(C)c4ccccc34)n2)c(OC)cc1N(C)CCN(C)Cc1ccccc1
Basic Information
| ChEMBL ID | CHEMBL5089161 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | IEUIFNRSXNCVOU-UHFFFAOYSA-N |
5
Targets
7
Activities
1
Assay Types
0
PK Parameters
7
Publications
0
Known Names
Molecular Properties
590.7
MW (Da)
6.16
ALogP
9
HBA
3
HBD
99.6
PSA (Ų)
0.14
QED
2
Ro5 Violations
13
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 7 meas. best 8.4
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| NCI-H1975 CHEMBL614348 | IC50 | 8.4 | 8.4 | 4.0 | 1 |
| Epidermal growth factor receptor CHEMBL203 | IC50 | 8.36 | 7.5667 | 4.4 | 3 |
| HCC827 CHEMBL4296422 | IC50 | 6.93 | 6.93 | 117.0 | 1 |
| A549 CHEMBL392 | IC50 | 5.58 | 5.58 | 2610.0 | 1 |
| NCI-H1299 CHEMBL612255 | IC50 | 5.4 | 5.4 | 3980.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| NCI-H1975 | IC50 | = | 4.02 | nM | 8.4 | Antiproliferative activity against human NCI-H1975 cells expressing EGFR T790M/L... | 34794818 |
| Epidermal growth factor receptor | IC50 | = | 4.363 | nM | 8.36 | Inhibition of EGFR T790M/C797S double mutant (unknown origin) using flurogenic s... | 34794818 |
| Epidermal growth factor receptor | IC50 | = | 11.23 | nM | 7.95 | Inhibition of EGFR del19 (unknown origin) using flurogenic substrate in presence... | 34794818 |
| HCC827 | IC50 | = | 117.0 | nM | 6.93 | Antiproliferative activity against human HCC827 cells expressing EGFR del119 mut... | 34794818 |
| Epidermal growth factor receptor | IC50 | = | 406.4 | nM | 6.39 | Inhibition of wild type EGFR (unknown origin) using flurogenic substrate in pres... | 34794818 |
| A549 | IC50 | = | 2610.0 | nM | 5.58 | Antiproliferative activity against human A549 cells expressing wild type EGFR as... | 34794818 |
| NCI-H1299 | IC50 | = | 3980.0 | nM | 5.4 | Antiproliferative activity against human NCI-H1299 cells expressing wild type EG... | 34794818 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 34794818 | 10.1016/j.ejmech.2021.113984 | Epidermal growth factor receptor | 3 |
| 34794818 | 10.1016/j.ejmech.2021.113984 | ADMET | 2 |
| 34794818 | 10.1016/j.ejmech.2021.113984 | Unchecked | 1 |
| 34794818 | 10.1016/j.ejmech.2021.113984 | NCI-H1975 | 1 |
| 34794818 | 10.1016/j.ejmech.2021.113984 | HCC827 | 1 |
| 34794818 | 10.1016/j.ejmech.2021.113984 | A549 | 1 |
| 34794818 | 10.1016/j.ejmech.2021.113984 | NCI-H1299 | 1 |
Data from ChEMBL 36 via Core Engine