Compound Detail
CHEMBL5093440
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Cc1noc(C)c1-c1cc(C(N)=O)c2c3ccc(C(C)(C)O)cc3n(C(c3ccccc3)c3ccccc3)c2c1
Basic Information
| ChEMBL ID | CHEMBL5093440 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | HVDQRLLMNXPXEE-UHFFFAOYSA-N |
2
Targets
3
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
529.6
MW (Da)
7.03
ALogP
5
HBA
2
HBD
94.3
PSA (Ų)
0.24
QED
2
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 8.82
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Bromodomain-containing protein 4 CHEMBL1163125 | IC50 | 8.82 | 8.82 | 1.5 | 1 |
| Unchecked CHEMBL612545 | IC50 | 8.41 | 8.185 | 3.9 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Bromodomain-containing protein 4 | IC50 | = | 1.5 | nM | 8.82 | Inhibition of human BRD4 (1 to 477 residues) measured after 60 mins by TR-FRET a... | 34543572 |
| Unchecked | IC50 | = | 3.9 | nM | 8.41 | Inhibition of c-MYC expression in human JJN3R cells measured after 4 hrs | 34543572 |
| Unchecked | IC50 | = | 11.0 | nM | 7.96 | Antitumour activity against human JJN3R cells measured after 72 hrs by MTS assay | 34543572 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 34543572 | 10.1021/acs.jmedchem.1c00625 | ADMET | 3 |
| 34543572 | 10.1021/acs.jmedchem.1c00625 | Unchecked | 2 |
| 34543572 | 10.1021/acs.jmedchem.1c00625 | Bromodomain-containing protein 4 | 1 |
Data from ChEMBL 36 via Core Engine