Compound Detail
CHEMBL511977
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COc1cc(Nc2nc(N[C@@H]3CCCC[C@@H]3N)n3cc(-c4ccccc4)nc3c2C(N)=O)cc(OC)c1
Basic Information
| ChEMBL ID | CHEMBL511977 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | UCDYGVBDFHZXEE-LEWJYISDSA-N |
2
Targets
3
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
501.6
MW (Da)
3.94
ALogP
9
HBA
4
HBD
141.8
PSA (Ų)
0.28
QED
1
Ro5 Violations
8
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 6.42
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Tyrosine-protein kinase SYK CHEMBL2599 | IC50 | 6.42 | 6.42 | 380.0 | 2 |
| Tyrosine-protein kinase ZAP-70 CHEMBL2803 | IC50 | 6.22 | 6.22 | 600.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Tyrosine-protein kinase SYK | IC50 | = | 380.0 | nM | 6.42 | Inhibition of human Syk expressed in Sf9 cells | 18823784 |
| Tyrosine-protein kinase SYK | IC50 | = | 380.0 | nM | 6.42 | Inhibition of recombinant Syk | 19254842 |
| Tyrosine-protein kinase ZAP-70 | IC50 | = | 600.0 | nM | 6.22 | Inhibition of human ZAP70 expressed in Sf9 cells | 18823784 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 18823784 | 10.1016/j.bmc.2008.09.015 | Tyrosine-protein kinase SYK | 1 |
| 18823784 | 10.1016/j.bmc.2008.09.015 | Tyrosine-protein kinase ZAP-70 | 1 |
| 19254842 | 10.1016/j.bmcl.2009.02.049 | Tyrosine-protein kinase SYK | 1 |
Data from ChEMBL 36 via Core Engine