Compound Detail
CHEMBL512338
LATRUNCULEIC ACID Enter ChEMBL ID:
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Basic Information
| ChEMBL ID | CHEMBL512338 |
| Name | LATRUNCULEIC ACID |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | OHWFPMKLBOHSHY-WKTSBRCASA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
292.4
MW (Da)
3.64
ALogP
3
HBA
1
HBD
63.6
PSA (Ų)
0.42
QED
0
Ro5 Violations
8
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 4.58
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| MDA-MB-435 CHEMBL614697 | IC50 | 4.58 | 4.58 | 26100.0 | 1 |
| HCT-116 CHEMBL394 | IC50 | 4.32 | 4.32 | 48000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| MDA-MB-435 | IC50 | = | 26100.0 | nM | 4.58 | Cytotoxicity against human MDA-MB-435 cells 48 hrs by SRB assay | 18942825 |
| HCT-116 | IC50 | = | 48000.0 | nM | 4.32 | Cytotoxicity against human HCT116 cells after 3 days by trypan blue assay | 18942825 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 18942825 | 10.1021/jm8008585 | MDA-MB-435 | 2 |
| 15217296 | 10.1021/np0340753 | A10 | 1 |
| 18942825 | 10.1021/jm8008585 | HCT-116 | 1 |
| 18942825 | 10.1021/jm8008585 | A10 | 1 |
Data from ChEMBL 36 via Core Engine