Assay Detail
Functional
CHEMBL946261
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Cytotoxicity against human HCT116 cells after 3 days by trypan blue assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Interrogating the bioactive pharmacophore of the latrunculin chemotype by investigating the metabolites of two taxonomically unrelated sponges.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 5.28 | 6.32 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL487774 | LATRUNCULOL A | — | 1 | 6.32 |
| CHEMBL485952 | LATRUNCULONE B | — | 1 | 6.04 |
| CHEMBL404116 | LATRUNCULIN A | — | 1 | 5.96 |
| CHEMBL485737 | LATRUNCULOL B | — | 1 | 5.68 |
| CHEMBL520559 | — | — | 1 | 5.29 |
| CHEMBL521352 | 18-EPI-LATRUNCULOL A | — | 1 | 5.26 |
| CHEMBL411879 | LATRUNCULIN B | — | 1 | 5.15 |
| CHEMBL471071 | 16-EPI-LATRUNCULIN B | — | 1 | 4.42 |
| CHEMBL512338 | LATRUNCULEIC ACID | — | 1 | 4.32 |
| CHEMBL471070 | 15-METHOXYLATRUNCULIN B | — | 1 | 4.31 |
| CHEMBL485924 | LATRUNCULIN C | — | 1 | - |
| CHEMBL486344 | LATRUNCULOL C | — | 1 | - |
| CHEMBL486345 | LATRUNCULONE A | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL487774 | LATRUNCULOL A | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL485952 | LATRUNCULONE B | IC50 | = | 920.0 | nM | 6.04 |
| CHEMBL404116 | LATRUNCULIN A | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL485737 | LATRUNCULOL B | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL520559 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL521352 | 18-EPI-LATRUNCULOL A | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL411879 | LATRUNCULIN B | IC50 | = | 7100.0 | nM | 5.15 |
| CHEMBL471071 | 16-EPI-LATRUNCULIN B | IC50 | = | 38000.0 | nM | 4.42 |
| CHEMBL512338 | LATRUNCULEIC ACID | IC50 | = | 48000.0 | nM | 4.32 |
| CHEMBL471070 | 15-METHOXYLATRUNCULIN B | IC50 | = | 49000.0 | nM | 4.31 |
| CHEMBL485924 | LATRUNCULIN C | IC50 | > | 100000.0 | nM | - |
| CHEMBL486344 | LATRUNCULOL C | IC50 | > | 53000.0 | nM | - |
| CHEMBL486345 | LATRUNCULONE A | IC50 | > | 53000.0 | nM | - |