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Compound Detail

CHEMBL516154

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CCCn1c(=O)c2[nH]c(-c3ccccc3)c(O)c2n(CCC)c1=O

Basic Information

ChEMBL ID CHEMBL516154
Phase Preclinical
Structure Type MOL
InChI Key WMMQZUWLDBUPNK-UHFFFAOYSA-N
4
Targets
4
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names

Molecular Properties

327.4
MW (Da)
2.68
ALogP
5
HBA
2
HBD
80.0
PSA (Ų)
0.76
QED
0
Ro5 Violations
5
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C18H21N3O3
MW 327.38
Aromatic Rings 3
Heavy Atoms 24
NP-Likeness -0.45

Activity Summary

Ki 4 meas. best 7.3

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Adenosine receptor A2a
CHEMBL251
Ki 7.3 7.3 50.0 1
Adenosine receptor A2b
CHEMBL255
Ki 7.27 7.27 54.0 1
Adenosine receptor A1
CHEMBL226
Ki 7.08 7.08 83.0 1
Adenosine receptor A3
CHEMBL256
Ki 6.74 6.74 182.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
18938084 10.1016/j.bmc.2008.09.067 Adenosine receptor A2b 1
18938084 10.1016/j.bmc.2008.09.067 Adenosine receptor A2a 1
18938084 10.1016/j.bmc.2008.09.067 Unchecked 1
18938084 10.1016/j.bmc.2008.09.067 Adenosine receptor A1 1
18938084 10.1016/j.bmc.2008.09.067 Adenosine receptor A3 1

Data from ChEMBL 36 via Core Engine