Compound Detail
CHEMBL5170159
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Basic Information
| ChEMBL ID | CHEMBL5170159 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | GUAMECUKAAOVCU-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
425.4
MW (Da)
3.34
ALogP
8
HBA
1
HBD
99.2
PSA (Ų)
0.46
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 5.93
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Fibroblast growth factor receptor 3 CHEMBL2742 | IC50 | 5.93 | 5.93 | 1177.0 | 1 |
| Fibroblast growth factor receptor 1 CHEMBL3650 | IC50 | 5.58 | 5.58 | 2648.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Fibroblast growth factor receptor 3 | IC50 | = | 1177.0 | nM | 5.93 | Inhibition of N-terminal His-Avi tagged recombinant human FGFR3 (447 to 761 resi... | 36356320 |
| Fibroblast growth factor receptor 1 | IC50 | = | 2648.0 | nM | 5.58 | Inhibition of recombinant human FGFR1 using biotin-EQEDEPEGDYFEWLE-amide as subs... | 36356320 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 36356320 | 10.1021/acs.jmedchem.2c01366 | Fibroblast growth factor receptor 3 | 1 |
| 36356320 | 10.1021/acs.jmedchem.2c01366 | Fibroblast growth factor receptor 1 | 1 |
Data from ChEMBL 36 via Core Engine