Compound Detail
CHEMBL5171754
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL5171754 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | WUIYGFLHCAIEJT-WOPDTQHZSA-N |
2
Targets
3
Activities
1
Assay Types
0
PK Parameters
7
Publications
0
Known Names
Molecular Properties
223.3
MW (Da)
-0.49
ALogP
4
HBA
4
HBD
72.7
PSA (Ų)
0.55
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 5.47
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Sucrase-isomaltase, intestinal CHEMBL3114 | IC50 | 5.47 | 5.47 | 3400.0 | 1 |
| Acidic alpha-glucosidase CHEMBL3513 | IC50 | 4.37 | 4.37 | 43000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Sucrase-isomaltase, intestinal | IC50 | = | 3400.0 | nM | 5.47 | Inhibition of rat intestinal sucrase assessed as release of p-nitrophenol using ... | 35255314 |
| Acidic alpha-glucosidase | IC50 | = | 43000.0 | nM | 4.37 | Inhibition of rat intestinal maltase assessed as release of D-glucose using malt... | 35255314 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 35255314 | 10.1016/j.ejmech.2022.114230 | Unchecked | 12 |
| 35255314 | 10.1016/j.ejmech.2022.114230 | Acidic alpha-glucosidase | 1 |
| 35255314 | 10.1016/j.ejmech.2022.114230 | Sucrase-isomaltase, intestinal | 1 |
| 35255314 | 10.1016/j.ejmech.2022.114230 | Lysosomal alpha-glucosidase | 1 |
| 35255314 | 10.1016/j.ejmech.2022.114230 | Alpha-galactosidase | 1 |
| 35255314 | 10.1016/j.ejmech.2022.114230 | Alpha-mannosidase | 1 |
| 35255314 | 10.1016/j.ejmech.2022.114230 | Tissue alpha-L-fucosidase | 1 |
Data from ChEMBL 36 via Core Engine