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Assay Detail

CHEMBL5135396

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of rat intestinal sucrase assessed as release of p-nitrophenol using p-nitrophenyl glycoside as substrate by spectrometric assay
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Rattus norvegicus
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Sucrase-isomaltase, intestinal (CHEMBL3114)
Type SINGLE PROTEIN
Organism Rattus norvegicus

Publication

Design, synthesis and glycosidase inhibition of C-4 branched LAB and DAB derivatives.
Wang JZ, Cheng B, Kato A, Kise M, Shimadate Y, Jia YM, Li YX, Fleet GWJ, Yu CY.
Eur J Med Chem (2022) 233 : 114230 -114230
PubMed 35255314 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 25 5.87 6.75

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5186198 1 6.75
CHEMBL5191437 1 6.70
CHEMBL5198563 1 6.64
CHEMBL5202712 1 6.48
CHEMBL5189075 1 6.32
CHEMBL2177689 1 6.19
CHEMBL5192700 1 6.17
CHEMBL5203897 1 6.13
CHEMBL5183794 1 6.02
CHEMBL406973 1 6.00
CHEMBL5193222 1 6.00
CHEMBL5195202 1 5.77
CHEMBL5199880 1 5.66
CHEMBL5090583 1 5.66
CHEMBL5207259 1 5.64
CHEMBL5180919 1 5.60
CHEMBL5197560 1 5.60
CHEMBL5201729 1 5.55
CHEMBL5171754 1 5.47
CHEMBL5196218 1 5.39
CHEMBL5194927 1 5.39
CHEMBL5175783 1 5.19
CHEMBL80254 1 4.80
CHEMBL5188686 1 -
CHEMBL5197630 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5186198 IC50 = 180.0 nM 6.75
CHEMBL5191437 IC50 = 200.0 nM 6.70
CHEMBL5198563 IC50 = 230.0 nM 6.64
CHEMBL5202712 IC50 = 330.0 nM 6.48
CHEMBL5189075 IC50 = 480.0 nM 6.32
CHEMBL2177689 IC50 = 640.0 nM 6.19
CHEMBL5192700 IC50 = 680.0 nM 6.17
CHEMBL5203897 IC50 = 740.0 nM 6.13
CHEMBL5183794 IC50 = 950.0 nM 6.02
CHEMBL406973 IC50 = 1000.0 nM 6.00
CHEMBL5193222 IC50 = 1000.0 nM 6.00
CHEMBL5195202 IC50 = 1700.0 nM 5.77
CHEMBL5199880 IC50 = 2200.0 nM 5.66
CHEMBL5090583 IC50 = 2200.0 nM 5.66
CHEMBL5207259 IC50 = 2300.0 nM 5.64
CHEMBL5180919 IC50 = 2500.0 nM 5.60
CHEMBL5197560 IC50 = 2500.0 nM 5.60
CHEMBL5201729 IC50 = 2800.0 nM 5.55
CHEMBL5171754 IC50 = 3400.0 nM 5.47
CHEMBL5196218 IC50 = 4100.0 nM 5.39
CHEMBL5194927 IC50 = 4100.0 nM 5.39
CHEMBL5175783 IC50 = 6500.0 nM 5.19
CHEMBL80254 IC50 = 16000.0 nM 4.80
CHEMBL5188686 IC50 = 455000.0 nM -
CHEMBL5197630 IC50 = 107000.0 nM -