Compound Detail
CHEMBL5180919
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL5180919 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | QGSDLTWUJJDJQM-ZWKOPEQDSA-N |
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
7
Publications
0
Known Names
Molecular Properties
269.3
MW (Da)
-0.78
ALogP
6
HBA
4
HBD
91.2
PSA (Ų)
0.57
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 5.6
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Sucrase-isomaltase, intestinal CHEMBL3114 | IC50 | 5.6 | 5.6 | 2500.0 | 1 |
| Acidic alpha-glucosidase CHEMBL3513 | IC50 | 4.22 | 4.22 | 60000.0 | 1 |
| Unchecked CHEMBL612545 | IC50 | 4.19 | 4.19 | 64000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Sucrase-isomaltase, intestinal | IC50 | = | 2500.0 | nM | 5.6 | Inhibition of rat intestinal sucrase assessed as release of p-nitrophenol using ... | 35255314 |
| Acidic alpha-glucosidase | IC50 | = | 60000.0 | nM | 4.22 | Inhibition of rat intestinal maltase assessed as release of D-glucose using malt... | 35255314 |
| Unchecked | IC50 | = | 64000.0 | nM | 4.19 | Inhibition of yeast alpha-glucosidase assessed as release of p-nitrophenol using... | 35255314 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 35255314 | 10.1016/j.ejmech.2022.114230 | Unchecked | 12 |
| 35255314 | 10.1016/j.ejmech.2022.114230 | Acidic alpha-glucosidase | 1 |
| 35255314 | 10.1016/j.ejmech.2022.114230 | Sucrase-isomaltase, intestinal | 1 |
| 35255314 | 10.1016/j.ejmech.2022.114230 | Lysosomal alpha-glucosidase | 1 |
| 35255314 | 10.1016/j.ejmech.2022.114230 | Alpha-galactosidase | 1 |
| 35255314 | 10.1016/j.ejmech.2022.114230 | Alpha-mannosidase | 1 |
| 35255314 | 10.1016/j.ejmech.2022.114230 | Tissue alpha-L-fucosidase | 1 |
Data from ChEMBL 36 via Core Engine