Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL5135400

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of yeast alpha-glucosidase assessed as release of p-nitrophenol using p-nitrophenyl glycoside as substrate by spectrometric assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Saccharomyces cerevisiae
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Design, synthesis and glycosidase inhibition of C-4 branched LAB and DAB derivatives.
Wang JZ, Cheng B, Kato A, Kise M, Shimadate Y, Jia YM, Li YX, Fleet GWJ, Yu CY.
Eur J Med Chem (2022) 233 : 114230 -114230
PubMed 35255314 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 15 4.72 6.82

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL80254 1 6.82
CHEMBL5195202 1 5.01
CHEMBL5186198 1 4.92
CHEMBL5199880 1 4.72
CHEMBL5193222 1 4.24
CHEMBL5183794 1 4.22
CHEMBL5180919 1 4.19
CHEMBL5203897 1 4.19
CHEMBL5191437 1 4.16
CHEMBL5188686 1 -
CHEMBL5196218 1 -
CHEMBL5201729 1 -
CHEMBL5197560 1 -
CHEMBL5171754 1 -
CHEMBL5194927 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL80254 IC50 = 150.0 nM 6.82
CHEMBL5195202 IC50 = 9800.0 nM 5.01
CHEMBL5186198 IC50 = 12000.0 nM 4.92
CHEMBL5199880 IC50 = 19000.0 nM 4.72
CHEMBL5193222 IC50 = 57000.0 nM 4.24
CHEMBL5183794 IC50 = 60000.0 nM 4.22
CHEMBL5180919 IC50 = 64000.0 nM 4.19
CHEMBL5203897 IC50 = 64000.0 nM 4.19
CHEMBL5191437 IC50 = 70000.0 nM 4.16
CHEMBL5188686 IC50 = 116000.0 nM -
CHEMBL5196218 IC50 = 528000.0 nM -
CHEMBL5201729 IC50 = 305000.0 nM -
CHEMBL5197560 IC50 = 388000.0 nM -
CHEMBL5171754 IC50 = 212000.0 nM -
CHEMBL5194927 IC50 = 243000.0 nM -