Compound Detail
CHEMBL5173615
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Basic Information
| ChEMBL ID | CHEMBL5173615 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | RMSBZAQRXXIXQF-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
249.7
MW (Da)
1.78
ALogP
5
HBA
3
HBD
95.2
PSA (Ų)
0.60
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 6.31
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Serine/threonine-protein kinase PLK4 CHEMBL3788 | IC50 | 6.31 | 6.31 | 489.1 | 1 |
| Serine/threonine-protein kinase PAK 4 CHEMBL4482 | IC50 | 5.23 | 5.23 | 5937.1 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Serine/threonine-protein kinase PLK4 | IC50 | = | 489.1 | nM | 6.31 | Inhibition of recombinant human PLK4 incubated for 60 mins by Lanthascreen Eu ki... | 35576702 |
| Serine/threonine-protein kinase PAK 4 | IC50 | = | 5937.1 | nM | 5.23 | Inhibition of PAK4 (unknown origin) incubated for 60 mins by time-resolved HTRF ... | 35576702 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 35576702 | 10.1016/j.ejmech.2022.114424 | Serine/threonine-protein kinase PLK4 | 1 |
| 35576702 | 10.1016/j.ejmech.2022.114424 | Serine/threonine-protein kinase PAK 4 | 1 |
| 35576702 | 10.1016/j.ejmech.2022.114424 | Unchecked | 1 |
Data from ChEMBL 36 via Core Engine