Compound Detail
CHEMBL5177019
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Basic Information
| ChEMBL ID | CHEMBL5177019 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | WEUTVUGITJRHGR-UHFFFAOYSA-N |
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
474.5
MW (Da)
2.99
ALogP
8
HBA
3
HBD
109.4
PSA (Ų)
0.48
QED
0
Ro5 Violations
7
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 5.21
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform CHEMBL5169092 | IC50 | 5.21 | 5.21 | 6185.0 | 1 |
| Unchecked CHEMBL612545 | IC50 | 5.04 | 5.04 | 9015.0 | 1 |
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform CHEMBL3608198 | IC50 | 5.03 | 5.03 | 9290.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | IC50 | = | 6185.0 | nM | 5.21 | Inhibition of PI3Kalpha in rat Rat1 cells assessed as reduction in phosphorylati... | 35500094 |
| Unchecked | IC50 | = | 9015.0 | nM | 5.04 | Inhibition of PI3Kdelta in rat Rat1 cells assessed as reduction in phosphorylati... | 35500094 |
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | IC50 | = | 9290.0 | nM | 5.03 | Inhibition of PI3Kbeta in rat Rat1 cells assessed as reduction in phosphorylatio... | 35500094 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 35500094 | 10.1021/acs.jmedchem.2c00267 | ADMET | 2 |
| 35500094 | 10.1021/acs.jmedchem.2c00267 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | 1 |
| 35500094 | 10.1021/acs.jmedchem.2c00267 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | 1 |
| 35500094 | 10.1021/acs.jmedchem.2c00267 | Unchecked | 1 |
Data from ChEMBL 36 via Core Engine