Compound Detail
CHEMBL5179451
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CNC(=O)c1ccc(-c2ccc(=O)n(CCc3ccc4ncc(-c5cnn(C)c5)cc4c3)n2)cc1
Basic Information
| ChEMBL ID | CHEMBL5179451 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | JZGQGBFKMPQJKF-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
464.5
MW (Da)
3.46
ALogP
7
HBA
1
HBD
94.7
PSA (Ų)
0.42
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 8.4
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Hepatocyte growth factor receptor CHEMBL3717 | IC50 | 8.4 | 8.4 | 4.0 | 1 |
| Hs746T CHEMBL614579 | IC50 | 6.86 | 6.86 | 137.3 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Hepatocyte growth factor receptor | IC50 | = | 4.0 | nM | 8.4 | Inhibition of N-terminal His/SUMO tagged wild type human c-Met (1038 to 1346 res... | 36355693 |
| Hs746T | IC50 | = | 137.3 | nM | 6.86 | Antiproliferative activity against human Hs746T cells harboring MET alterations ... | 36355693 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 36355693 | 10.1021/acs.jmedchem.2c00981 | Hepatocyte growth factor receptor | 1 |
| 36355693 | 10.1021/acs.jmedchem.2c00981 | Hs746T | 1 |
Data from ChEMBL 36 via Core Engine