Compound Detail
CHEMBL5189074
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Basic Information
| ChEMBL ID | CHEMBL5189074 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | QLRGZHSLCMSKID-UHFFFAOYSA-N |
2
Targets
3
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
332.4
MW (Da)
2.16
ALogP
6
HBA
1
HBD
77.1
PSA (Ų)
0.62
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 7.66
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Fibroblast growth factor receptor 3 CHEMBL2742 | IC50 | 7.66 | 7.415 | 22.0 | 2 |
| Fibroblast growth factor receptor 1 CHEMBL3650 | IC50 | 6.04 | 6.04 | 918.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Fibroblast growth factor receptor 3 | IC50 | = | 22.0 | nM | 7.66 | Inhibition of recombinant human FGFR3 V555L mutant using biotin-EQEDEPEGDYFEWLE-... | 36356320 |
| Fibroblast growth factor receptor 3 | IC50 | = | 68.0 | nM | 7.17 | Inhibition of N-terminal His-Avi tagged recombinant human FGFR3 (447 to 761 resi... | 36356320 |
| Fibroblast growth factor receptor 1 | IC50 | = | 918.0 | nM | 6.04 | Inhibition of recombinant human FGFR1 using biotin-EQEDEPEGDYFEWLE-amide as subs... | 36356320 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 36356320 | 10.1021/acs.jmedchem.2c01366 | Fibroblast growth factor receptor 3 | 2 |
| 36356320 | 10.1021/acs.jmedchem.2c01366 | Fibroblast growth factor receptor 1 | 1 |
Data from ChEMBL 36 via Core Engine