Compound Detail
CHEMBL5189340
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Basic Information
| ChEMBL ID | CHEMBL5189340 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | WQIVPDKBAHQPEF-LQKURTRISA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
474.0
MW (Da)
3.86
ALogP
6
HBA
1
HBD
79.6
PSA (Ų)
0.33
QED
0
Ro5 Violations
7
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 10.64
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Vascular endothelial growth factor receptor 2 CHEMBL279 | IC50 | 10.64 | 10.64 | 0.0 | 1 |
| Epidermal growth factor receptor CHEMBL203 | IC50 | 9.35 | 9.35 | 0.5 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Vascular endothelial growth factor receptor 2 | IC50 | = | 0.023 | nM | 10.64 | Inhibition of VEGFR-2 (unknown origin) | 33129590 |
| Epidermal growth factor receptor | IC50 | = | 0.45 | nM | 9.35 | Inhibition of EGFR (unknown origin) | 33129590 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 33129590 | 10.1016/j.ejmech.2020.112946 | Vascular endothelial growth factor receptor 2 | 1 |
| 33129590 | 10.1016/j.ejmech.2020.112946 | Epidermal growth factor receptor | 1 |
Data from ChEMBL 36 via Core Engine