Compound Detail
CHEMBL5198774
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CN1Cc2c(Cl)cc(Cl)cc2C(c2cccc(S(=O)(=O)NCCOCCNC(=O)C(O)C(O)NCCOCCNS(=O)(=O)c3cccc(C4CN(C)Cc5c(Cl)cc(Cl)cc54)c3)c2)C1
Basic Information
| ChEMBL ID | CHEMBL5198774 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | GVXPHYRSXOCUEY-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
1002.9
MW (Da)
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 6.5
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Sodium/hydrogen exchanger 3 CHEMBL3273 | IC50 | 6.5 | 6.5 | 316.2 | 1 |
| Sodium/hydrogen exchanger 3 CHEMBL3879842 | IC50 | 5.8 | 5.8 | 1584.9 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Sodium/hydrogen exchanger 3 | IC50 | = | 316.23 | nM | 6.5 | Inhibition of human NHE3 expressed in opossum kidney cells assessed as reduction... | 35859876 |
| Sodium/hydrogen exchanger 3 | IC50 | = | 1584.89 | nM | 5.8 | Inhibition of rat NHE3 expressed in opossum kidney cells assessed as reduction i... | 35859876 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 35859876 | 10.1021/acsmedchemlett.2c00037 | Unchecked | 3 |
| 35859876 | 10.1021/acsmedchemlett.2c00037 | Sodium/hydrogen exchanger 3 | 2 |
Data from ChEMBL 36 via Core Engine