Compound Detail
CHEMBL520782
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Basic Information
| ChEMBL ID | CHEMBL520782 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | FCSLYUBEYDUDTP-UHFFFAOYSA-N |
2
Targets
3
Activities
1
Assay Types
2
PK Parameters
10
Publications
0
Known Names
Molecular Properties
410.4
MW (Da)
3.42
ALogP
9
HBA
1
HBD
113.0
PSA (Ų)
0.47
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 3 meas. best 8.62
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Adenosine receptor A2a CHEMBL251 | Ki | 8.62 | 8.62 | 2.4 | 2 |
| Adenosine receptor A1 CHEMBL226 | Ki | 6.39 | 6.39 | 406.0 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| AUC | 1405.0 | ng.hr.mL-1 | Rattus norvegicus |
| AUC | 1405.0 | ng.hr.mL-1 | Rattus norvegicus |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Adenosine receptor A2a | Ki | = | 2.4 | nM | 8.62 | Antagonist activity at human adenosine A2A receptor | 18562199 |
| Adenosine receptor A2a | Ki | = | 2.4 | nM | 8.62 | Inhibition of human recombinant adenosine receptor A2a | 24164628 |
| Adenosine receptor A1 | Ki | = | 406.0 | nM | 6.39 | Inhibition of human recombinant adenosine A1 receptor | 24164628 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 18562199 | 10.1016/j.bmcl.2008.05.074 | Rattus norvegicus | 3 |
| 24164628 | 10.1021/jm4011669 | Rattus norvegicus | 3 |
| 18562199 | 10.1016/j.bmcl.2008.05.074 | Adenosine receptor A2a | 1 |
| 18562199 | 10.1016/j.bmcl.2008.05.074 | Unchecked | 1 |
| 18562199 | 10.1016/j.bmcl.2008.05.074 | No relevant target | 1 |
| 24164628 | 10.1021/jm4011669 | Unchecked | 1 |
| 24164628 | 10.1021/jm4011669 | Adenosine receptor A2b | 1 |
| 24164628 | 10.1021/jm4011669 | Adenosine receptor A2a | 1 |
| 24164628 | 10.1021/jm4011669 | Adenosine receptor A1 | 1 |
| 24164628 | 10.1021/jm4011669 | Adenosine receptor A3 | 1 |
Data from ChEMBL 36 via Core Engine