Compound Detail
CHEMBL5207902
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Basic Information
| ChEMBL ID | CHEMBL5207902 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | CKTHSNKTNFUNPZ-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
331.4
MW (Da)
4.85
ALogP
4
HBA
1
HBD
43.0
PSA (Ų)
0.55
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 6.27
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Short transient receptor potential channel 5 CHEMBL1250411 | IC50 | 6.27 | 6.27 | 540.0 | 1 |
| Short transient receptor potential channel 4 CHEMBL4295971 | IC50 | 5.69 | 5.69 | 2060.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Short transient receptor potential channel 5 | IC50 | = | 540.0 | nM | 6.27 | Inhibition of human TRPC5 channel expressed in HEK293 cells assessed as inhibiti... | 35653869 |
| Short transient receptor potential channel 4 | IC50 | = | 2060.0 | nM | 5.69 | Inhibition of human TRPC4 channel expressed in HEK293 cells assessed as inhibiti... | 35653869 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 35653869 | 10.1016/j.bmc.2022.116853 | Unchecked | 5 |
| 35653869 | 10.1016/j.bmc.2022.116853 | Short transient receptor potential channel 5 | 1 |
| 35653869 | 10.1016/j.bmc.2022.116853 | Short transient receptor potential channel 4 | 1 |
Data from ChEMBL 36 via Core Engine