Compound Detail
CHEMBL520851
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Basic Information
| ChEMBL ID | CHEMBL520851 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | QIHMPEZAXBQNBF-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
306.4
MW (Da)
4.24
ALogP
4
HBA
2
HBD
44.6
PSA (Ų)
0.74
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 6.21
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Methyl-CpG-binding protein 2 CHEMBL3638346 | IC50 | 6.21 | 6.21 | 610.0 | 1 |
| Methyl-CpG-binding domain protein 2 CHEMBL3707462 | IC50 | 6.17 | 6.17 | 670.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Methyl-CpG-binding protein 2 | IC50 | = | 610.0 | nM | 6.21 | Binding Assay: DNA binding assays using recombinant MBDs. To produce recombinant... | - |
| Methyl-CpG-binding domain protein 2 | IC50 | = | 670.0 | nM | 6.17 | Binding Assay: DNA binding assays using recombinant MBDs. To produce recombinant... | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 19489590 | 10.1021/jm801399r | Unchecked | 1 |
Data from ChEMBL 36 via Core Engine