Compound Detail
CHEMBL5220723
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Basic Information
| ChEMBL ID | CHEMBL5220723 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | LSPFWDKIFNVOIF-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
428.9
MW (Da)
2.41
ALogP
8
HBA
1
HBD
91.3
PSA (Ų)
0.58
QED
0
Ro5 Violations
7
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 7.91
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Adenylate cyclase type 10 CHEMBL5854 | IC50 | 7.91 | 7.91 | 12.3 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Adenylate cyclase type 10 | IC50 | = | 12.3 | nM | 7.91 | Inhibition of human ADCY10 assessed as cAMP accumulation preincubated for 15 min... | 36346696 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 36346696 | 10.1021/acs.jmedchem.2c01133 | Adenylate cyclase type 10 | 2 |
Data from ChEMBL 36 via Core Engine