Assay Detail
Binding
CHEMBL5218088
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Inhibition of human ADCY10 assessed as cAMP accumulation preincubated for 15 mins followed by substrate addition using alpha-32P labelled ATP as substrate by sequential chromatographic analysis
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, Synthesis, and Pharmacological Evaluation of Second-Generation Soluble Adenylyl Cyclase (sAC, ADCY10) Inhibitors with Slow Dissociation Rates.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 31 | 7.38 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5220685 | — | — | 1 | 9.00 |
| CHEMBL5218878 | — | — | 1 | 8.68 |
| CHEMBL5218552 | — | — | 1 | 8.66 |
| CHEMBL5218615 | — | — | 1 | 8.62 |
| CHEMBL5219830 | — | — | 1 | 8.48 |
| CHEMBL5219579 | — | — | 1 | 8.48 |
| CHEMBL5218698 | — | — | 1 | 8.41 |
| CHEMBL5218702 | — | — | 1 | 8.40 |
| CHEMBL5220647 | — | — | 1 | 8.34 |
| CHEMBL5219443 | — | — | 1 | 8.26 |
| CHEMBL5220895 | — | — | 1 | 8.17 |
| CHEMBL5220347 | — | — | 1 | 8.11 |
| CHEMBL5220723 | — | — | 1 | 7.91 |
| CHEMBL5219922 | — | — | 1 | 7.77 |
| CHEMBL5219530 | — | — | 1 | 7.68 |
| CHEMBL5220632 | — | — | 1 | 7.62 |
| CHEMBL5221008 | — | — | 1 | 7.19 |
| CHEMBL5220075 | — | — | 1 | 7.17 |
| CHEMBL5221093 | — | — | 1 | 7.06 |
| CHEMBL5219193 | — | — | 1 | 6.95 |
| CHEMBL4854762 | — | — | 1 | 6.80 |
| CHEMBL4867202 | — | — | 1 | 6.46 |
| CHEMBL5219159 | — | — | 1 | 6.41 |
| CHEMBL5219933 | — | — | 1 | 6.36 |
| CHEMBL5220308 | — | — | 1 | 6.33 |
| CHEMBL5219011 | — | — | 1 | 6.14 |
| CHEMBL5218555 | — | — | 1 | 6.08 |
| CHEMBL4874934 | — | — | 1 | 5.99 |
| CHEMBL5218712 | — | — | 1 | 5.91 |
| CHEMBL5219751 | — | — | 1 | 5.73 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5220685 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL5218878 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL5218552 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL5218615 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL5219830 | — | IC50 | = | 3.33 | nM | 8.48 |
| CHEMBL5219579 | — | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL5218698 | — | IC50 | = | 3.9 | nM | 8.41 |
| CHEMBL5218702 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL5220647 | — | IC50 | = | 4.6 | nM | 8.34 |
| CHEMBL5219443 | — | IC50 | = | 5.5 | nM | 8.26 |
| CHEMBL5220895 | — | IC50 | = | 6.7 | nM | 8.17 |
| CHEMBL5220347 | — | IC50 | = | 7.8 | nM | 8.11 |
| CHEMBL5220723 | — | IC50 | = | 12.3 | nM | 7.91 |
| CHEMBL5219922 | — | IC50 | = | 16.9 | nM | 7.77 |
| CHEMBL5219530 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL5220632 | — | IC50 | = | 24.2 | nM | 7.62 |
| CHEMBL5221008 | — | IC50 | = | 64.0 | nM | 7.19 |
| CHEMBL5220075 | — | IC50 | = | 67.0 | nM | 7.17 |
| CHEMBL5221093 | — | IC50 | = | 87.1 | nM | 7.06 |
| CHEMBL5219193 | — | IC50 | = | 112.0 | nM | 6.95 |
| CHEMBL4854762 | — | IC50 | = | 159.0 | nM | 6.80 |
| CHEMBL4867202 | — | IC50 | = | 351.0 | nM | 6.46 |
| CHEMBL5219159 | — | IC50 | = | 389.0 | nM | 6.41 |
| CHEMBL5219933 | — | IC50 | = | 436.0 | nM | 6.36 |
| CHEMBL5220308 | — | IC50 | = | 469.0 | nM | 6.33 |
| CHEMBL5219011 | — | IC50 | = | 716.0 | nM | 6.14 |
| CHEMBL5218555 | — | IC50 | = | 829.0 | nM | 6.08 |
| CHEMBL4874934 | — | IC50 | = | 1024.0 | nM | 5.99 |
| CHEMBL5218712 | — | IC50 | = | 1245.0 | nM | 5.91 |
| CHEMBL5219751 | — | IC50 | = | 1876.0 | nM | 5.73 |
| CHEMBL5220138 | — | IC50 | = | 2577.0 | nM | 5.59 |