Compound Detail
CHEMBL524112
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Basic Information
| ChEMBL ID | CHEMBL524112 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | IRWZBGNDKQQJKD-DIACKHNESA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
343.4
MW (Da)
-0.75
ALogP
9
HBA
4
HBD
121.0
PSA (Ų)
0.57
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 2 meas. best 5.1
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Glycogen phosphorylase, muscle form CHEMBL4696 | Ki | 5.1 | 5.095 | 8000.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Glycogen phosphorylase, muscle form | Ki | = | 8000.0 | nM | 5.1 | Inhibition of rabbit muscle glycogen phosphorylase b | 18793852 |
| Glycogen phosphorylase, muscle form | Ki | = | 8200.0 | nM | 5.09 | Inhibition of rabbit muscle glycogen phosphorylase b by Dixon plot analysis | 19574053 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 18793852 | 10.1016/j.bmcl.2008.08.052 | Glycogen phosphorylase, muscle form | 1 |
| 19574053 | 10.1016/j.bmc.2009.05.080 | Glycogen phosphorylase, muscle form | 1 |
Data from ChEMBL 36 via Core Engine