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Assay Detail

CHEMBL983534

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Binding
Inhibition of rabbit muscle glycogen phosphorylase b
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Oryctolagus cuniculus
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Glycogen phosphorylase, muscle form (CHEMBL4696)
Type SINGLE PROTEIN
Organism Oryctolagus cuniculus

Publication

Novel design principle validated: glucopyranosylidene-spiro-oxathiazole as new nanomolar inhibitor of glycogen phosphorylase, potential antidiabetic agent.
Somsák L, Nagy V, Vidal S, Czifrák K, Berzsényi E, Praly JP.
Bioorg Med Chem Lett (2008) 18 : 5680 -5683
PubMed 18793852 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 14 5.21 6.80

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL490175 1 6.80
CHEMBL490001 1 6.46
CHEMBL510975 1 5.51
CHEMBL489799 1 5.34
CHEMBL490000 1 5.30
CHEMBL489798 1 5.29
CHEMBL524112 1 5.10
CHEMBL488967 1 5.00
CHEMBL523952 1 4.58
CHEMBL489972 1 4.55
CHEMBL3351143 1 4.50
CHEMBL3351140 1 4.09
CHEMBL443455 1 -
CHEMBL450104 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL490175 Ki = 160.0 nM 6.80
CHEMBL490001 Ki = 350.0 nM 6.46
CHEMBL510975 Ki = 3100.0 nM 5.51
CHEMBL489799 Ki = 4600.0 nM 5.34
CHEMBL490000 Ki = 5000.0 nM 5.30
CHEMBL489798 Ki = 5100.0 nM 5.29
CHEMBL524112 Ki = 8000.0 nM 5.10
CHEMBL488967 Ki = 10000.0 nM 5.00
CHEMBL523952 Ki = 26000.0 nM 4.58
CHEMBL489972 Ki = 28000.0 nM 4.55
CHEMBL3351143 Ki = 32000.0 nM 4.50
CHEMBL3351140 Ki = 81000.0 nM 4.09
CHEMBL443455 Ki = 305000.0 nM -
CHEMBL450104 Ki = 444000.0 nM -