Compound Detail
CHEMBL5267611
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Basic Information
| ChEMBL ID | CHEMBL5267611 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | LSRBAFLNXOUPIC-UHFFFAOYSA-N |
3
Targets
5
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
437.5
MW (Da)
0.36
ALogP
9
HBA
1
HBD
108.3
PSA (Ų)
0.61
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 5 meas. best 7.82
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Fibroblast growth factor receptor 3 CHEMBL2742 | IC50 | 7.82 | 7.82 | 15.0 | 1 |
| Fibroblast growth factor receptor 1 CHEMBL3650 | IC50 | 6.55 | 6.535 | 283.0 | 2 |
| Activin receptor type-1 CHEMBL5903 | IC50 | 5.9 | 5.9 | 1250.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Fibroblast growth factor receptor 3 | IC50 | = | 15.0 | nM | 7.82 | Inhibition of recombinant N-terminal His-Avi-tag human FGFR3 (447 to 761 residue... | 36923909 |
| Fibroblast growth factor receptor 1 | IC50 | = | 283.0 | nM | 6.55 | Inhibition of recombinant human wild type FGFR1 (399 to 820 residues) using biot... | 36923909 |
| Fibroblast growth factor receptor 1 | IC50 | = | 300.0 | nM | 6.52 | Enzymatic Assay: un-Phosphorylated (UP): The inhibitor potency of the exemplifie... | - |
| Activin receptor type-1 | IC50 | = | 1250.0 | nM | 5.9 | HTRF Assay (3 uM ATP): ALK2 (aa 147-end) was obtained from BPS biosciences. The ... | - |
| Activin receptor type-1 | IC50 | = | 1250.0 | nM | 5.9 | HTRF Assay (100 uM ATP): ALK2 (aa 147-end) was obtained from BPS biosciences. Th... | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 36923909 | 10.1021/acsmedchemlett.3c00003 | Fibroblast growth factor receptor 3 | 1 |
| 36923909 | 10.1021/acsmedchemlett.3c00003 | Fibroblast growth factor receptor 1 | 1 |
| 36923909 | 10.1021/acsmedchemlett.3c00003 | Unchecked | 1 |
Data from ChEMBL 36 via Core Engine