Compound Detail
CHEMBL5271637
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Basic Information
| ChEMBL ID | CHEMBL5271637 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | NZOSRLDMRAAASX-KSSFIOAISA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
420.4
MW (Da)
3.05
ALogP
5
HBA
2
HBD
75.2
PSA (Ų)
0.80
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 2 meas. best 10.7
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| N-formyl peptide receptor 2 CHEMBL4227 | EC50 | 10.7 | 10.7 | 0.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| N-formyl peptide receptor 2 | EC50 | = | 0.02 | nM | 10.7 | Agonist activity at FPR2 (unknown origin) assessed as increase in calcium flux | 33486199 |
| N-formyl peptide receptor 2 | EC50 | = | 0.02 | nM | 10.7 | Agonist activity at FPR2 (unknown origin) expressed in CHO cells by cAMP assay | 38199163 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 33486199 | 10.1016/j.ejmech.2021.113167 | N-formyl peptide receptor 2 | 1 |
| 38199163 | 10.1016/j.ejmech.2023.115989 | N-formyl peptide receptor 2 | 1 |
Data from ChEMBL 36 via Core Engine