Compound Detail
CHEMBL5272088
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Basic Information
| ChEMBL ID | CHEMBL5272088 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | SJLAAMAKAKHNLF-HNNXBMFYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
385.4
MW (Da)
2.58
ALogP
7
HBA
1
HBD
102.8
PSA (Ų)
0.54
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 6.59
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Fibroblast growth factor receptor 2 CHEMBL4142 | IC50 | 6.59 | 6.59 | 255.0 | 1 |
| Epidermal growth factor receptor CHEMBL203 | IC50 | 6.13 | 6.13 | 741.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Fibroblast growth factor receptor 2 | IC50 | = | 255.0 | nM | 6.59 | Inhibition of human recombinant cytoplasmic domain FGFR2 (8 to 134 residues) inc... | 37077386 |
| Epidermal growth factor receptor | IC50 | = | 741.0 | nM | 6.13 | Inhibition of recombinant human EGFR del19/T790M using biotinEEPLYWSFPAKKK-NH2 a... | 37077386 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 37077386 | 10.1021/acsmedchemlett.3c00006 | Fibroblast growth factor receptor 2 | 1 |
| 37077386 | 10.1021/acsmedchemlett.3c00006 | Epidermal growth factor receptor | 1 |
Data from ChEMBL 36 via Core Engine