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Compound Detail

CHEMBL5273574

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Cn1cc(-c2nc(Nc3cccc([N+](=O)[O-])c3)ncc2F)cn1

Basic Information

ChEMBL ID CHEMBL5273574
Phase Preclinical
Structure Type MOL
InChI Key BQMSNFVGBGXSDZ-UHFFFAOYSA-N
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names

Molecular Properties

314.3
MW (Da)
2.67
ALogP
7
HBA
1
HBD
98.8
PSA (Ų)
0.59
QED
0
Ro5 Violations
4
Rot. Bonds

Drug Information

Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C14H11FN6O2
MW 314.28
Aromatic Rings 3
Heavy Atoms 23
NP-Likeness -2.31

Activity Summary

Ki 2 meas. best 7.06

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Cyclin-dependent kinase 2/cyclin E
CHEMBL2094126
Ki 7.06 7.06 87.0 1
CDK9/cyclin T1
CHEMBL2111389
Ki 6.83 6.83 147.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
36706608 10.1016/j.bmc.2023.117158 Cyclin-dependent kinase 1/cyclin B 1
36706608 10.1016/j.bmc.2023.117158 Cyclin-dependent kinase 2/cyclin E 1
36706608 10.1016/j.bmc.2023.117158 Cyclin-dependent kinase 5/CDK5 activator 1 1
36706608 10.1016/j.bmc.2023.117158 CDK9/cyclin T1 1
36706608 10.1016/j.bmc.2023.117158 A2780 1

Data from ChEMBL 36 via Core Engine