Compound Detail
CHEMBL5274203
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Basic Information
| ChEMBL ID | CHEMBL5274203 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | NPARLOLYJZFLKX-HNNXBMFYSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
408.4
MW (Da)
3.18
ALogP
6
HBA
2
HBD
88.8
PSA (Ų)
0.68
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 8.29
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| cGMP-dependent 3',5'-cyclic phosphodiesterase CHEMBL2652 | IC50 | 8.29 | 8.29 | 5.1 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| cGMP-dependent 3',5'-cyclic phosphodiesterase | IC50 | = | 5.1 | nM | 8.29 | Inhibition of PDE2A (unknown origin) | 33412421 |
| cGMP-dependent 3',5'-cyclic phosphodiesterase | IC50 | = | 5.1 | nM | 8.29 | Proximity Ligation Assay: Isolated cardiomyocytes were washed twice in PBS at ro... | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 33412421 | 10.1016/j.ejmech.2020.113123 | cGMP-dependent 3',5'-cyclic phosphodiesterase | 1 |
Data from ChEMBL 36 via Core Engine