Compound Detail
CHEMBL5274760
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Basic Information
| ChEMBL ID | CHEMBL5274760 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | KKZLZOHIFUHFSI-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
452.5
MW (Da)
1.90
ALogP
10
HBA
1
HBD
101.2
PSA (Ų)
0.49
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 6.9
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Fibroblast growth factor receptor 4 CHEMBL3973 | IC50 | 6.9 | 6.9 | 127.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Fibroblast growth factor receptor 4 | IC50 | = | 127.0 | nM | 6.9 | Inhibition of FGFR4 (unknown origin) using TK as substrate incubated for 1 hr in... | 36480917 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 36480917 | 10.1021/acs.jmedchem.2c01420 | Fibroblast growth factor receptor 4 | 1 |
Data from ChEMBL 36 via Core Engine