Compound Detail
CHEMBL5275455
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Basic Information
| ChEMBL ID | CHEMBL5275455 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | JZCCPTBBVGMQKW-UHFFFAOYSA-N |
6
Targets
6
Activities
1
Assay Types
0
PK Parameters
6
Publications
0
Known Names
Molecular Properties
254.2
MW (Da)
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 6 meas. best 5.46
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| 184B5 CHEMBL4296396 | IC50 | 5.46 | 5.46 | 3500.0 | 1 |
| BEAS-2B CHEMBL4296403 | IC50 | 5.29 | 5.29 | 5100.0 | 1 |
| Unchecked CHEMBL612545 | IC50 | 5.21 | 5.21 | 6200.0 | 1 |
| DU-145 CHEMBL613508 | IC50 | 5.15 | 5.15 | 7100.0 | 1 |
| HT-29 CHEMBL384 | IC50 | 5.14 | 5.14 | 7200.0 | 1 |
| MCF7 CHEMBL387 | IC50 | 4.21 | 4.21 | 62200.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| 184B5 | IC50 | = | 3500.0 | nM | 5.46 | Antiproliferative activity against human 184B5 cells incubated for 48 hrs by MTT... | 36257283 |
| BEAS-2B | IC50 | = | 5100.0 | nM | 5.29 | Antiproliferative activity against human BEAS-2B cells incubated for 48 hrs by M... | 36257283 |
| Unchecked | IC50 | = | 6200.0 | nM | 5.21 | Antiproliferative activity against human HTB-54 cells incubated for 48 hrs by MT... | 36257283 |
| DU-145 | IC50 | = | 7100.0 | nM | 5.15 | Antiproliferative activity against human DU-145 cells incubated for 48 hrs by MT... | 36257283 |
| HT-29 | IC50 | = | 7200.0 | nM | 5.14 | Antiproliferative activity against human HT-29 cells incubated for 48 hrs by MTT... | 36257283 |
| MCF7 | IC50 | = | 62200.0 | nM | 4.21 | Antiproliferative activity against human MCF7 cells incubated for 48 hrs by MTT ... | 36257283 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 36257283 | 10.1016/j.ejmech.2022.114839 | Unchecked | 3 |
| 36257283 | 10.1016/j.ejmech.2022.114839 | DU-145 | 1 |
| 36257283 | 10.1016/j.ejmech.2022.114839 | HT-29 | 1 |
| 36257283 | 10.1016/j.ejmech.2022.114839 | MCF7 | 1 |
| 36257283 | 10.1016/j.ejmech.2022.114839 | 184B5 | 1 |
| 36257283 | 10.1016/j.ejmech.2022.114839 | BEAS-2B | 1 |
Data from ChEMBL 36 via Core Engine