Compound Detail
CHEMBL5276622
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Basic Information
| ChEMBL ID | CHEMBL5276622 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | ICBFITLMTVXRNS-LBPRGKRZSA-N |
2
Targets
4
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names
Molecular Properties
386.2
MW (Da)
2.19
ALogP
3
HBA
4
HBD
107.5
PSA (Ų)
0.58
QED
0
Ro5 Violations
7
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 4 meas. best 9.24
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| fMet-Leu-Phe receptor CHEMBL3359 | EC50 | 9.24 | 9.24 | 0.6 | 2 |
| N-formyl peptide receptor 2 CHEMBL4227 | EC50 | 6.66 | 6.655 | 220.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| fMet-Leu-Phe receptor | EC50 | = | 0.58 | nM | 9.24 | Agonist activity at FPR1 (unknown origin) expressed in CHO/Galpha16 cells assess... | 33486199 |
| fMet-Leu-Phe receptor | EC50 | = | 0.58 | nM | 9.24 | Agonist activity at FPR1 (unknown origin) transfected in CHO cells assessed as i... | 38199163 |
| N-formyl peptide receptor 2 | EC50 | = | 220.0 | nM | 6.66 | Agonist activity at FPR2 (unknown origin) transfected in CHO cells assessed as i... | 38199163 |
| N-formyl peptide receptor 2 | EC50 | = | 224.0 | nM | 6.65 | Agonist activity at FPR2 (unknown origin) expressed in CHO/Galpha16 cells assess... | 33486199 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 33486199 | 10.1016/j.ejmech.2021.113167 | fMet-Leu-Phe receptor | 2 |
| 33486199 | 10.1016/j.ejmech.2021.113167 | N-formyl peptide receptor 2 | 2 |
| 33486199 | 10.1016/j.ejmech.2021.113167 | Unchecked | 1 |
| 38199163 | 10.1016/j.ejmech.2023.115989 | fMet-Leu-Phe receptor | 1 |
| 38199163 | 10.1016/j.ejmech.2023.115989 | N-formyl peptide receptor 2 | 1 |
Data from ChEMBL 36 via Core Engine