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Compound Detail

CHEMBL5279839

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CC(C)N1CN(C2c3ccccc3CSc3ccccc32)n2cc(C(=O)O)c(=O)c(O)c2C1=O

Basic Information

ChEMBL ID CHEMBL5279839
Phase Preclinical
Structure Type MOL
InChI Key TZYCSBPXQNJQIR-UHFFFAOYSA-N
3
Targets
4
Activities
2
Assay Types
0
PK Parameters
2
Publications
0
Known Names

Molecular Properties

477.5
MW (Da)
3.41
ALogP
7
HBA
2
HBD
103.1
PSA (Ų)
0.60
QED
0
Ro5 Violations
3
Rot. Bonds

Drug Information

Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C25H23N3O5S
MW 477.54
Aromatic Rings 3
Heavy Atoms 34
NP-Likeness -0.34

Activity Summary

EC50 3 meas. best 8.44
IC50 1 meas. best 6.92

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Junin virus
CHEMBL4523072
EC50 8.44 8.44 3.6 1
Mammarenavirus choriomeningitidis
CHEMBL5291622
EC50 8.1 8.1 8.0 1
Unchecked
CHEMBL612545
IC50 6.92 6.92 121.0 1
Unchecked
CHEMBL612545
EC50 6.8 6.8 160.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
36758821 10.1016/j.bmcl.2023.129175 Junin virus 2
36758821 10.1016/j.bmcl.2023.129175 Mammarenavirus choriomeningitidis 2

Data from ChEMBL 36 via Core Engine