Compound Detail
CHEMBL5286212
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Basic Information
| ChEMBL ID | CHEMBL5286212 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | UWZFWAKDXDFCQH-INIZCTEOSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
423.3
MW (Da)
2.99
ALogP
3
HBA
4
HBD
116.8
PSA (Ų)
0.40
QED
0
Ro5 Violations
7
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 2 meas. best 9.18
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| N-formyl peptide receptor 2 CHEMBL4227 | EC50 | 9.18 | 9.18 | 0.7 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| N-formyl peptide receptor 2 | EC50 | = | 0.66 | nM | 9.18 | Agonist activity at human FPR2 expressed in HEK293 cells assessed as increase in... | 33486199 |
| N-formyl peptide receptor 2 | EC50 | = | 0.66 | nM | 9.18 | Agonist activity at human FPR2 | 38199163 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 33486199 | 10.1016/j.ejmech.2021.113167 | N-formyl peptide receptor 2 | 1 |
| 33486199 | 10.1016/j.ejmech.2021.113167 | Mus musculus | 1 |
| 38199163 | 10.1016/j.ejmech.2023.115989 | N-formyl peptide receptor 2 | 1 |
Data from ChEMBL 36 via Core Engine