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Assay Detail

CHEMBL5524108

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Functional
Agonist activity at human FPR2
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

N-formyl peptide receptor 2 (CHEMBL4227)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

The formyl peptide receptors FPR1 and FPR2 as targets for inflammatory disorders: recent advances in the development of small-molecule agonists.
Yi X, Tran E, Odiba JO, Qin CX, Ritchie RH, Baell JB.
Eur J Med Chem (2024) 265 : 115989 -115989
PubMed 38199163 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 10 8.93 10.15

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL552527 1 10.15
CHEMBL5287715 1 9.60
CHEMBL4784510 BMS-986235 1.0 1 9.39
CHEMBL5286212 1 9.18
CHEMBL5564062 1 8.92
CHEMBL5555475 1 8.62
CHEMBL5560735 1 8.42
CHEMBL5282051 1 8.39
CHEMBL379761 1 7.66
CHEMBL564392 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL552527 EC50 = 0.07 nM 10.15
CHEMBL5287715 EC50 = 0.25 nM 9.60
CHEMBL4784510 BMS-986235 EC50 = 0.41 nM 9.39
CHEMBL5286212 EC50 = 0.66 nM 9.18
CHEMBL5564062 EC50 = 1.2 nM 8.92
CHEMBL5555475 EC50 = 2.4 nM 8.62
CHEMBL5560735 EC50 = 3.8 nM 8.42
CHEMBL5282051 EC50 = 4.1 nM 8.39
CHEMBL379761 EC50 = 22.0 nM 7.66
CHEMBL564392 EC50 > 50.0 nM -