Compound Detail
CHEMBL5303523
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL5303523 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | LKOFXMLMYKWELM-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
20
Publications
0
Known Names
Molecular Properties
404.5
MW (Da)
2.70
ALogP
8
HBA
2
HBD
91.2
PSA (Ų)
0.69
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 8.82
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| NUAK family SNF1-like kinase 1 CHEMBL5784 | IC50 | 8.82 | 8.82 | 1.5 | 1 |
| Unchecked CHEMBL612545 | IC50 | 6.22 | 6.22 | 600.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| NUAK family SNF1-like kinase 1 | IC50 | = | 1.5 | nM | 8.82 | Inhibition of GST-tagged NUAK1 (unknown origin) expressed in HEK293 cells using ... | 24171924 |
| Unchecked | IC50 | = | 600.0 | nM | 6.22 | Inhibition of GST-tagged NUAK1 A195T (unknown origin) expressed in HEK293 cells ... | 24171924 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| - | 10.6019/CHEMBL5303304 | U2OS | 9 |
| - | 10.6019/CHEMBL5303304 | HEK-293T | 8 |
| - | 10.6019/CHEMBL5303304 | Fibroblast | 5 |
| 24171924 | 10.1042/bj20131152 | Unchecked | 2 |
| 24171924 | 10.1042/bj20131152 | NUAK family SNF1-like kinase 1 | 2 |
| 24171924 | 10.1042/bj20131152 | AMPK alpha1/beta2/gamma1 | 1 |
| 24171924 | 10.1042/bj20131152 | Tyrosine-protein kinase JAK2 | 1 |
| 24171924 | 10.1042/bj20131152 | Tyrosine-protein kinase ABL1 | 1 |
| 24171924 | 10.1042/bj20131152 | Aurora kinase B | 1 |
| 24171924 | 10.1042/bj20131152 | Aurora kinase A | 1 |
| 24171924 | 10.1042/bj20131152 | NUAK family SNF1-like kinase 2 | 1 |
| - | 10.6019/CHEMBL5308504 | Bromodomain-containing protein 4 | 1 |
| - | 10.6019/CHEMBL5308504 | Transcription intermediary factor 1-alpha | 1 |
| - | 10.6019/CHEMBL5308504 | Peregrin | 1 |
| - | 10.6019/CHEMBL5308504 | Fibroblast growth factor receptor 3 | 1 |
| - | 10.6019/CHEMBL5308504 | Tyrosine-protein kinase ABL1 | 1 |
| - | 10.6019/CHEMBL5308504 | Aurora kinase A | 1 |
| - | 10.6019/CHEMBL5308504 | Mitogen-activated protein kinase 1 | 1 |
| - | 10.6019/CHEMBL5308504 | Glycogen synthase kinase-3 beta | 1 |
| - | 10.6019/CHEMBL5308504 | Cyclin-dependent kinase 2 | 1 |
Data from ChEMBL 36 via Core Engine