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Compound Detail

CHEMBL53093

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Oc1ccc(Nc2cc(-c3ccc4ccccc4c3)nc3ccccc23)cc1

Basic Information

ChEMBL ID CHEMBL53093
Phase Preclinical
Structure Type MOL
InChI Key WPRSYWMNVDOMLM-UHFFFAOYSA-N
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names

Molecular Properties

362.4
MW (Da)
6.50
ALogP
3
HBA
2
HBD
45.1
PSA (Ų)
0.36
QED
1
Ro5 Violations
3
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C25H18N2O
MW 362.43
Aromatic Rings 5
Heavy Atoms 28
NP-Likeness -0.52

Activity Summary

EC50 2 meas. best 6.5

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
NON-PROTEIN TARGET
CHEMBL3879801
EC50 6.5 6.5 320.0 1
WEHI
CHEMBL612804
EC50 6.5 6.5 316.2 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
10406648 10.1016/s0960-894x(99)00291-7 NON-PROTEIN TARGET 1
17049254 10.1016/j.bmc.2006.09.059 WEHI 1

Data from ChEMBL 36 via Core Engine