Assay Detail
Functional
CHEMBL818651
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Concentration required for half-maximal inhibition of CpG-ODN effect on thymidine uptake by WEHI 231 murine B-cells in the presence of alpha-sIgM.
34
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | WEHI 231 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Structure-activity relationship analysis of substituted 4-quinolinamines, antagonists of immunostimulatory CpG-oligodeoxynucleotides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 34 | 7.19 | 9.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL53633 | — | — | 1 | 9.62 |
| CHEMBL300500 | — | — | 1 | 8.92 |
| CHEMBL53923 | — | — | 1 | 8.82 |
| CHEMBL53369 | — | — | 1 | 8.40 |
| CHEMBL54239 | — | — | 1 | 8.23 |
| CHEMBL53362 | — | — | 1 | 8.19 |
| CHEMBL53034 | — | — | 1 | 8.04 |
| CHEMBL52235 | — | — | 1 | 8.00 |
| CHEMBL297479 | — | — | 1 | 7.96 |
| CHEMBL298731 | — | — | 1 | 7.96 |
| CHEMBL22086 | — | — | 1 | 7.94 |
| CHEMBL21808 | — | — | 1 | 7.91 |
| CHEMBL300104 | — | — | 1 | 7.60 |
| CHEMBL50928 | — | — | 1 | 7.40 |
| CHEMBL53315 | — | — | 1 | 7.29 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 6.96 |
| CHEMBL50752 | — | — | 1 | 6.81 |
| CHEMBL52866 | — | — | 1 | 6.77 |
| CHEMBL53869 | — | — | 1 | 6.50 |
| CHEMBL53093 | — | — | 1 | 6.50 |
| CHEMBL51685 | — | — | 1 | 6.48 |
| CHEMBL52196 | — | — | 1 | 6.38 |
| CHEMBL53036 | — | — | 1 | 6.32 |
| CHEMBL53147 | — | — | 1 | 6.29 |
| CHEMBL52607 | — | — | 1 | 6.24 |
| CHEMBL418449 | — | — | 1 | 6.00 |
| CHEMBL301543 | — | — | 1 | 5.94 |
| CHEMBL301560 | — | — | 1 | 5.62 |
| CHEMBL300655 | — | — | 1 | 5.36 |
| CHEMBL54188 | — | — | 1 | 5.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL53633 | — | EC50 | = | 0.24 | nM | 9.62 |
| CHEMBL300500 | — | EC50 | = | 1.2 | nM | 8.92 |
| CHEMBL53923 | — | EC50 | = | 1.5 | nM | 8.82 |
| CHEMBL53369 | — | EC50 | = | 4.0 | nM | 8.40 |
| CHEMBL54239 | — | EC50 | = | 5.9 | nM | 8.23 |
| CHEMBL53362 | — | EC50 | = | 6.5 | nM | 8.19 |
| CHEMBL53034 | — | EC50 | = | 9.1 | nM | 8.04 |
| CHEMBL52235 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL297479 | — | EC50 | = | 11.0 | nM | 7.96 |
| CHEMBL298731 | — | EC50 | = | 11.0 | nM | 7.96 |
| CHEMBL22086 | — | EC50 | = | 11.5 | nM | 7.94 |
| CHEMBL21808 | — | EC50 | = | 12.3 | nM | 7.91 |
| CHEMBL300104 | — | EC50 | = | 25.1 | nM | 7.60 |
| CHEMBL50928 | — | EC50 | = | 39.8 | nM | 7.40 |
| CHEMBL53315 | — | EC50 | = | 51.3 | nM | 7.29 |
| CHEMBL76 | CHLOROQUINE | EC50 | = | 110.0 | nM | 6.96 |
| CHEMBL50752 | — | EC50 | = | 155.0 | nM | 6.81 |
| CHEMBL52866 | — | EC50 | = | 170.0 | nM | 6.77 |
| CHEMBL53869 | — | EC50 | = | 316.0 | nM | 6.50 |
| CHEMBL53093 | — | EC50 | = | 320.0 | nM | 6.50 |
| CHEMBL51685 | — | EC50 | = | 330.0 | nM | 6.48 |
| CHEMBL52196 | — | EC50 | = | 416.0 | nM | 6.38 |
| CHEMBL53036 | — | EC50 | = | 478.0 | nM | 6.32 |
| CHEMBL53147 | — | EC50 | = | 510.0 | nM | 6.29 |
| CHEMBL52607 | — | EC50 | = | 570.0 | nM | 6.24 |
| CHEMBL418449 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL301543 | — | EC50 | = | 1150.0 | nM | 5.94 |
| CHEMBL301560 | — | EC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL300655 | — | EC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL54188 | — | EC50 | = | 7600.0 | nM | 5.12 |
| CHEMBL52012 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL51273 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL52032 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL53582 | — | EC50 | > | 10000.0 | nM | - |